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Sildenafil citrate, commonly known by the brand name, is a prescription-only medicine used to treat erectile dysfunction (ED) in adult men. It works by improving blood flow to the penis, helping to achieve and maintain an erection during sexual activity.

Dosage and Administration

Sildenafil is available in 25mg, 50mg, and 100mg strengths.

  • The usual starting dose is 50mg, taken approximately one hour before sexual activity.
  • Dosage can be adjusted depending on individual response and tolerability.
  • Take only one tablet in 24 hours, with or without food.
  • Avoid grapefruit juice, as it can increase the risk of side effects.
  • A high-fat meal may delay onset of action.

Effectiveness

Sildenafil has been shown to be effective in up to 80% of men with ED, with effects typically noticeable within 30 to 60 minutes, and lasting for up to 4–5 hours.

Side Effects

Common side effects include:

  • Headache
  • Flushing
  • Nasal congestion
  • Indigestion

Less common but serious effects include visual disturbances, hearing changes, or prolonged erections. Seek medical attention if severe or persistent side effects occur.

Contraindications

Sildenafil should not be used by those:

  • Taking nitrates for chest pain
  • With severe heart or liver conditions
  • Under 18 years of age
  • With certain medication interactions (e.g. alpha-blockers, antifungals, antibiotics)

Interactions

Inform your doctor of all medications and supplements before use. Interactions may occur with:

  • Nitrates
  • Alpha-blockers
  • Some antibiotics and antifungal medicines

Alcohol and Heart Conditions

Avoid excessive alcohol while taking sildenafil, as it can lower blood pressure and increase side effect risk. Use with caution if you have any heart-related conditions.

Availability and Cost

Sildenafil is available by prescription only in the UK.

  • Generic versions are more affordable than branded Viagra.
  • Supplied by licensed UK pharmacies such as Online Chemist.
  • Avoid counterfeit products from unregulated websites.

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Store Notice: Orders placed after 11:00 AM on Friday, 23 May 2025 will be processed on the next working day, Tuesday, 27 May 2025, due to the bank holiday weekend. Thank you for your understanding.

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The following is a summary of the clinical evidence of the safety of sildenafil citrate. We have provided a list of some of the key information about sildenafil citrate as an on-label medication, including its dosing, indications and benefits, risks and benefits. A full list of the benefits is provided in

.

Sildenafil citrate is indicated for the treatment of erectile dysfunction in men with a mean International Index of Erectile Function (IIEF) score of 5 or less, and for the treatment of pulmonary arterial hypertension in men with a mean International Index of Erectile Function (IIEF) score of 10 or greater. Sildenafil is also indicated for the treatment of pulmonary arterial hypertension in men with a mean IIEF score of 10 or greater. Sildenafil is also indicated for the treatment of benign prostatic hyperplasia in men with a mean IIEF score of 10 or greater. The clinical indication for sildenafil is for use as an adjunct to other medications and is indicated in cases where other indications for sildenafil are not suitable or do not exist. The safety and effectiveness of sildenafil in patients with erectile dysfunction treated with a PDE5 inhibitor have not been established. Sildenafil has no effect on premature ejaculation. The safety of sildenafil citrate in men with benign prostatic hyperplasia and other risk factors for the development of benign prostatic hyperplasia has not been established.

Table 1:Dosage and Administration of Sildenafil Citrate

Key Clinical Evidence

Sildenafil is a selective PDE5 inhibitor. Sildenafil is rapidly absorbed from the oral capsule, with peak plasma concentrations achieved within 30 minutes of oral administration. Sildenafil has a half-life of about 2 hours and it can take up to 2 hours for half the drug to be eliminated from the body, and only about half of the drug can be fully absorbed.

Sildenafil citrate is only approved for the treatment of erectile dysfunction. A number of other medications for ED have also been indicated for use in the treatment of this condition, including:

  • PDE5 Inhibitors (e.g., Viagra®, Cialis®, Levitra®)
  • Other PDE5 Inhibitors (e.g., Vardenafil®, Stendra®, Spedra®)
  • Vardenafil (Levitra®)
  • Vardenafil citrate (Vardenafil®)
  • Stendra® (Spedra®)

In addition to its effect on the IIEF scale, sildenafil has other clinical benefits. It is well tolerated. However, there are some adverse effects that can be reported, including:

  • A decrease in sexual desire
  • An increase in erectile response, but this is not observed in men taking a monoamine oxidase inhibitor (MAOI), such as selective serotonin reuptake inhibitors (SSRIs)
  • An increase in blood flow to the penile region
  • An increase in the volume of ejaculate

The safety of sildenafil citrate has not been established for all of these other PDE5 inhibitors. In men taking other medications for ED, sildenafil can cause unwanted effects that are not typically reported. In men with erectile dysfunction, sildenafil can cause adverse reactions, including:

  • Dizziness
  • Nausea
  • Headache
  • Dry mouth
  • Insomnia
  • Agitation
  • Decreased sexual desire
  • An increase in the incidence of priapism, a prolonged erection that causes damage to the penis

There have been reports of side effects associated with the use of sildenafil citrate. A full list of the possible side effects is available in

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Sildenafil (Viagra) is a, the most popular prescription medication used to treat erectile dysfunction (ED) and the symptoms of benign prostatic hyperplasia (BPH). Sildenafil contains the active ingredient sildenafil citrate and is available as a generic medicine. It is available in various strengths including 25mg, 50mg, 100mg. In June 2020, the injection became available without a prescription and is known as the [ ] Pfizer generic.

It is the active ingredient in Viagra and works by increasing blood flow to the penis. The mechanism of action of Sildenafil is not fully understood, but it is believed to be an effects on the enzyme phosphodiesterase type 5 (PDE5). PDE5 is the common pathway in which the body’s smooth muscle to increase blood flow to the penis and the presence of PDE5 is responsible for erectile dysfunction. Sildenafil helps to relax muscles in the penis and increase blood flow by enhancing the action of nitric oxide (NO) which is a muscle in the relaxation process.

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Sildenafil citrate, commonly known by the brand name, is a prescription-only medicine used to treat erectile dysfunction (ED) in adult men. It works by improving blood flow to the penis, helping to achieve and maintain an erection during sexual activity.

Dosage and Administration

Sildenafil is available in 25mg, 50mg, and 100mg strengths.

  • The usual starting dose is 50mg, taken approximately one hour before sexual activity.
  • Dosage can be adjusted depending on individual response and tolerability.
  • Take only one tablet in 24 hours, with or without food.
  • Avoid grapefruit juice, as it can increase the risk of side effects.
  • A high-fat meal may delay onset of action.

Effectiveness

Sildenafil has been shown to be effective in up to 80% of men with ED, with effects typically noticeable within 30 to 60 minutes, and lasting for up to 4–5 hours.

Side Effects

Common side effects include:

  • Headache
  • Flushing
  • Nasal congestion
  • Indigestion

Less common but serious effects include visual disturbances, hearing changes, or prolonged erections. Seek medical attention if severe or persistent side effects occur.

Contraindications

Sildenafil should not be used by those:

  • Taking nitrates for chest pain
  • With severe heart or liver conditions
  • Under 18 years of age
  • With certain medication interactions (e.g. alpha-blockers, antifungals, antibiotics)

Interactions

Inform your doctor of all medications and supplements before use. Interactions may occur with:

  • Nitrates
  • Alpha-blockers
  • Some antibiotics and antifungal medicines

Alcohol and Heart Conditions

Avoid excessive alcohol while taking sildenafil, as it can lower blood pressure and increase side effect risk. Use with caution if you have any heart-related conditions.

Availability and Cost

Sildenafil is available by prescription only in the UK.

  • Generic versions are more affordable than branded Viagra.
  • Supplied by licensed UK pharmacies such as Online Chemist.
  • Avoid counterfeit products from unregulated websites.

Take Control of Your Sex Life

Don’t let ED affect your confidence or relationships. Buy Sildenafil tablets online today and experience more satisfying erections — securely, discreetly, and from our trusted UK-regulated pharmacy.

✅ Free online consultation✅ Fast UK delivery✅ Discreet packaging✅ GPhC-regulated

now and get back to enjoying intimacy with confidence.

Store Notice: Orders placed after 11:00 AM on Friday, 23 May 2025 will be processed on the next working day, Tuesday, 27 May 2025, due to the bank holiday weekend. Thank you for your understanding.

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